Registration Dossier
Registration Dossier
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EC number: 203-721-0 | CAS number: 109-94-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- other: secondary source
- Title:
- Formic acid, ethyl ester
- Author:
- RTECS
- Year:
- 2 013
- Bibliographic source:
- RTECS
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute inhalation toxicity of the given test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl formate
- EC Number:
- 203-721-0
- EC Name:
- Ethyl formate
- Cas Number:
- 109-94-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- ethyl formate
- Details on test material:
- - IUPAC Name: Ethyl formate
- InChI: 1S/C3H6O2/c1-2-5-3-4/h3H,2H2,1H3
- Smiles: O(CC)C=O
- Molecular formula :C3H6O2
- Molecular weight :74.0784 g/mol
- Substance type:Organic
- Physical state:liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Remarks on duration:
- not specified
- Concentrations:
- 28950 mg/m3
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 28 950 mg/m³ air
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute inhalation LC50 value was considered to be 28950 mg/m3, when rats were treated with the given test chemical by inhalation route.
- Executive summary:
Acute inhalation toxicity study of the given test chemical was conducted in rats at the dose concentration of 28950 mg/m3.
Animals were observed for mortality. No mortality was observed at 28950 mg/m3.
Therefore, the LC50 value was considered to be 28950 mg/m3, when rats were treated with the given test chemical by inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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