Ethyl formate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Justification for type of information:

Data is from study report.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

Acute oral toxicity test of the given test chemical in rat.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl formate

EC Number:

203-721-0

EC Name:

Ethyl formate

Cas Number:

109-94-4

Molecular formula:

C3H6O2

IUPAC Name:

ethyl formate

Details on test material:

- IUPAC Name: Ethyl formate
- InChI - 1S/C3H6O2/c1-2-5-3-4/h3H,2H2,1H3
- Smiles - O(CC)C=O
- Molecular formula:C3H6O2
- Molecular weight :74.0784 g/mole
- Substance type:Organic

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

not specified

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Remarks:

15-35 % emulsion in 0.5% aqueous carboxymethylcellulose preparation

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 5600 mg/kg
- Amount of vehicle (if gavage): The product was administered as 15-35% emulsion in 0.5% aqueous carboxymethylcellulose preparation

Doses:

5600 mg/kg

No. of animals per sex per dose:

not specified

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: Animals were observed for mortality and clinical signs.
- Other examinations performed: Animals were observed for symptoms of intoxication, macroscopical examination.

Statistics:

not specified

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

5 600 mg/kg bw

Based on:

test mat.

Remarks on result:

other: 50% mortality was observed

Mortality:

50% mortality was observed

Clinical signs:

other: Symptoms of poisoning such as tumbling, apathy, dyspnoea, abdominal lateral position, spasmodic twitching, partly spastic gait, and cyanosis was observed in animals.

Gross pathology:

Acute cardiac dilation on both sides, acute congestive hyperemia, loam color liver with peripheral lappchenzeichnung(drawing) was observed.

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: Not classified

Conclusions:

The LD50 value was considered to be 5600 mg/kg bw, when rats were treated with the given test chemical via oral gavage route.

Executive summary:

The acute oral toxicity of the given test chemical was tested in rat at the dose concentration of 5600 mg/kg bw.

The given test chemical was administered as 15-35% emulsion in 0.5% aqueous carboxymethylcellulose preparation. Animals were observed for mortality and clinical signs for 7days. Also the symptoms of intoxication, macroscopic examination were performed.

50% mortality observed was observed. Symptoms of poisoning such as tumbling, apathy, dyspnoea, abdominal lateral position, spasmodic twitching, partly spastic gait, and cyanosis was observed in animals. Acute cardiac dilation on both sides, acute congestive hyperemia, loam color liver with peripheral lappchenzeichnung(drawing) was observed.

Therefore, thar LD₅₀value was considered to be 5600 mg/kg bw, when rats were treated with test chemical via oral gavage route.