Registration Dossier
Registration Dossier
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EC number: 252-354-2 | CAS number: 35086-59-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.04.1985 - 27.04.1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted in GLP compliance and according to an OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,5-Diacetoxyacetophenon
- IUPAC Name:
- 3,5-Diacetoxyacetophenon
- Details on test material:
- Charge: 96
Analysenattest vom 10.01.1984
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Fa. Dr. Karl Thomae GmbH, Biberach/Riss
- Age at study initiation: ca. 8 Monate
- Weight at study initiation: ca. 2 kg
- Housing: Einzelhaltung in Drahtkäfigen
- Diet (e.g. ad libitum): Kaninchenzuchtfutter
- Water (e.g. ad libitum): ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 20 mg
- Observation period (in vivo):
- 1 h, 24 h, 48 h und 72 h nach der Verabreichung
- Number of animals or in vitro replicates:
- 2 males and 2 females
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 0
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Es wurde bei allen Tieren eine leichte
Rötung der Konjunktiva eine Stunde post
appl. beobachtet. Nach 24 Stunden waren
diese Veränderungen verschwunden.
Die Substanz 3,5-Diacetoxyacetophenon wird
deshalb als schleimhautverträglich beurteilt.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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