Esterification products of dihydrofuran-2,5-dione, C16-24 (even numbered) alkenyl with propane-1,2,3-triol and propane-1,2,3-triol oligomers

Endpoint summary

Additional information

In accordance with column 2 of REACh Annex VIII a hydrolysis study does not need to be conducted if the substance is readily biodegradable or highly insoluble in water. The test item is a complex mixture for which the test guidelines for hydrolysis are not recommended. This is not only because components could have different hydrolytic rates but also hydrolysis products can be analytically indistinguishable from the starting components. The water solubility of the test item as a whole was expected to be loading rate dependent but for some of the components it was expected to be very low. Therefore, the test solution concentration required that would dissolve all the components would be impractically low in order to perform the test and a sufficiently sensitive analytical method was not available. Overall, these issues would make hydrolysis testing unfeasible. The main functional groups in the components of the test item are esters. Although esters usually readily hydrolyze, especially in alkaline conditions, some components of the test item may have a reduced hydrolytic potential due to them being essentially hydrophobic. An assessment of hydrolysis potential was obtained through the computer estimation programme Episuite v 3.12 using a MW of 1433. The half-lives of 76.932 days and 2.106 years were obtained for pH 8 and 7 respectively.