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EC number: 203-804-1
CAS number: 110-80-5
Results subchronic oral gavage rat (13 weeks):
At doses of 50, 100 and 100/400 µL/kg/day (increased dosage from 100 to
400 µL/kg at day 59 of the study period) no treatment related systemic
changes in the analysed organs were observed. The administration of 200
µL/kg/day resulted in all 5 male rats in obvious changes in the testes
(interstitium loosened oedematously). In the tubuli there was a lack of
the last ripening step from the normally arranged germinal epithelium to
the spermatocytes. In the spleens of all animals haemosiderin deposits
were observed. Nearly same results were observed in the dose group
200/800 µL/kg/day (increased dosage from 200 to 800 µL/kg at day 59 of
the study period).
Results subacute subcutaneous injection rat (4 weeks):
The administration of 400 µL/kg/day resulted in all 5 male rats in
obvious changes in the testes (interstitium loosened oedematously), lack
of further ripening steps of the spermatocytes in the tubuli. These
changes were more severe in the 800 µL/kg/day dose group.
Results subchronic oral gavage (gelatine capsules) dog (13 weeks):
At doses of 50 and 100 µL/kg/day no macroscopic nor histological
treatment related systemic changes in the analysed organs were observed.
At 200 µL/kg/day changes of the testes in the 3 male dogs were seen. In
2 male and one female slight changes were observed at the kidneys.
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