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EC number: 203-804-1
CAS number: 110-80-5
Results for rats (4 weeks, sc.):
At doses of 100 and 200 µL/kg/day the injection sites showed slight
chronic inflammation, but these were also observed in the corresponding
control group (subcutaneous injection of physiological saline). At 400
µL/kg additionally to the slight chronic inflammation at the injection
sites the 5 male rats showed testicular damage. In all animals of this
dosage group changes in the liver and kidneys was observed. The
observartions in the 800 µL/kg/day dose-group were the same as in the
lower dose group, but more severe.
Results for dogs (22 days, iv.):
In no dose group histological changes of the inner organs were observed.
At 100 µL/kg/day slight inflammation was observed at the injection
sites, in two cases there was thrombosis of a vein. At 500 µL/kg/day all
animals showed a predominant thrombophlebitis with severe
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