Registration Dossier
Registration Dossier
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EC number: 215-158-8 | CAS number: 1308-14-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro DNA damage and/or repair study
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information from a peer reviewed Assessment Report, original study not available.
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxicity of chromiumcompounds a review
- Author:
- De Flora S., Bagnasco M., Serra D., Zanacchi P.
- Year:
- 1 990
- Bibliographic source:
- Mutation Research 238 (2), 99-172
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline followed
- GLP compliance:
- not specified
- Type of assay:
- other: differential killing, streak method
Test material
- Reference substance name:
- Chromium (III) hydroxide
- EC Number:
- 215-158-8
- EC Name:
- Chromium (III) hydroxide
- Cas Number:
- 1308-14-1
- Molecular formula:
- CrH3O3
- IUPAC Name:
- chromium (III) hydroxide
- Test material form:
- solid - liquid: suspension
- Remarks:
- migrated information: dispersion
Constituent 1
Method
- Details on test system and experimental conditions:
- Dose: 50mg/L
Results and discussion
Test results
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Remarks on result:
- other: other: no data
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Data on in vitro genotoxicity of other poorly soluble and insoluble Chromium(III) compounds are reviewed, including Chromium(III) oxide (Cr2O3), chromite ore (Cr2O3· Fe2O3· Al2O3) and cupric chromite (Cr2O3· 2CuO). These compounds were genotoxic only, when contaminated with Cr(VI).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
In a single study with Chromium(III) hydroxide by in E. coli no DNA damage was seen. - Executive summary:
Water-insoluble chromium(III) compounds were studied. In a single study with Chromium(III) hydroxide by Yagi & Nishioka (1977) in E. coli no DNA damage was seen.
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