Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-053-9 | CAS number: 756-80-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
Spraque-Dawley rats were exposed to 0,004, 0,025 og 0,2 mg/l 6h/day, 5 day/week in 14 weeks.
In the test with male rats the animals exposed to the highest dose became sterile. At lower doses damages were observed at the male reproductive organs.
In the study with females the reporduction was not affected. Neighter were the offspring.
In conclusion methyl thioacid produced lesions in the eye, nasal passages, skeletal muscle, thyroid glands, epididymides and testes.
Short description of key information:
Monsanto conducted a fertility- study " Fertility, reproduction and fourteen-week inhalation toxicity with methyl thioacid in Sparhue-Dawley rats". The study consisted in 3 studies: "Male fertility study" , "Female fertility and Reproduction Study" and "Fourteen-week Inhalation study".
The purpose of these studies was to examine the toxicity of inhaled methyl thioacid in Spraque-Dawley rats and there offspring. These studies were preformed to further examine the effects observed in a previous methyl thioacid study.
The animals in these tree studies were exposed concurrently. The studies were conducted in 1984-1985 at the Envirinment Health Laboratory, St. Louis, Missouri.
Monsanto has accepted that the study is refered to for REACH purposes.
Justification for classification or non-classification
The study lead to the classification Rep3
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
