Registration Dossier
Registration Dossier
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EC number: 212-053-9 | CAS number: 756-80-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Search for Environmental Cancerogens
- Author:
- J. Szarapinska-Kwaszowska, M. Rozalska
- Year:
- 1 982
- Bibliographic source:
- Bromat, Chem. Toksykol.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 0,0-dimethylodithiofosforan
- IUPAC Name:
- 0,0-dimethylodithiofosforan
Constituent 1
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Additional information on results:
- Ames test using S. typhimurium his- auxotropic mutants, was applied. No mutagenic action was found. Neither directly nor in the presenco of rat liver microsomal fraction
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
No other information
Applicant's summary and conclusion
- Conclusions:
- MP-1 (0,0-dimethyl hydrogen dithiophosphate) was found not to be mutagenic in the presence and in the absence of metabolic activation when tested both in procaryotes and mammalian cells.
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