Registration Dossier
Registration Dossier
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EC number: 212-053-9 | CAS number: 756-80-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1981
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- HEDSET dataset
- Author:
- European Comission - European Chemicals Bureau
- Year:
- 1 994
- Bibliographic source:
- European Comission - Erupean Chemicals Bureau
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 6 groups of five male and female rats were exposed for 4 hour in a Rochester style exposure chamber and observed for 14 days hereafter.
- GLP compliance:
- no
- Test type:
- other:
Test material
- Reference substance name:
- O,O-dimethyl hydrogen dithiophosphate
- EC Number:
- 212-053-9
- EC Name:
- O,O-dimethyl hydrogen dithiophosphate
- Cas Number:
- 756-80-9
- Molecular formula:
- C2H7O2PS2
- IUPAC Name:
- O,O-dimethyl hydrogen dithiophosphate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other:
- Details on inhalation exposure:
- The walls of the exposure chamber and the animals were coated with the test material at all concentration levels. Therefore, snimals were exposed orally and dermally to grreater amount of methylthioacid than indicated by the concentrations
- Duration of exposure:
- 4 h
- Concentrations:
- The analyzed concentrations were: 0.89 mg/l, 1.14 mg/l, 1.20 mg/l, 1.23 mg/l, 1.28 mg/l, 1.64 mg/l,
- No. of animals per sex per dose:
- 6 groups og 5 animals
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 1.96 mg/L air (analytical)
- Based on:
- test mat.
Applicant's summary and conclusion
- Conclusions:
- LD50 inhalation for rat (combiened sex) 1.96 mg/l at 4 h
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