Registration Dossier
Registration Dossier
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EC number: 231-912-9 | CAS number: 7778-74-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Limited data are available and mostly come from secondary sources. The ATSDR Review of perchlorate toxicity (US EPA, 2008) concludes that the available data suggest that perchlorate is not a mutagenic or clastogenic agent. Cited in vitro data include a negative study of the induction of the SOS response in Salmonella typhimurium strain TA1535, a negative assay for the induction of DNA-protein crosslinks in cultured human lymphocytes and the absence of reverse mutation in an Ames test performed in six strains of Salmonella typhimurium. A negative response is also reported in a mouse lymphoma assay performed in the absence and presence of metabolic activation.
In vivo data are limited to a negative mouse bone marrow micronucleus assay performed at dose levels of up to 500 mg/kg bw (on three consecutive days by intraperitoneal injection). It is also notable that the 90-day oral toxicity study (Siglin et al, 2000) did not identify any increase in the proportion of micronucleated bone marrow PCEs following treatment with ammonium perchlorate at dose levels of up to 10 mg/kg bw/d administered in the drinking water.
A second published review (Mattie et al, 2006; Perchlorate Toxicity and Risk Assessment, United States Air Force Research / United States Department of Defense) also concludes that ‘genotoxicity assays showed that perchlorate has no toxic effects on genes or chromosomes in cells’. The therapeutic use of perchlorate salts (including potassium perchlorate) in humans for the treatment of hyperthyroidism over several decades also indicates an absence of genetic toxicity.
The available data therefore indicate that potassium perchlorate is not genotoxic.
Justification for selection of genetic toxicity endpoint
Higher tier sudy confirming the weight of evidence from review papers
Short description of key information:
Data are limited to review papers and confirmed by an absence of micronucleus induction in the 90-day toxicity study.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The available data indicate that potassium perchlorate is not genotoxic; no classification is proposed.
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