Registration Dossier
Registration Dossier
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EC number: 231-912-9 | CAS number: 7778-74-7
Specific investigations: other studies
Administrative data
Link to relevant study record(s)
Description of key information
Additional information
Exposure to perchlorate during prepubertal period of development does not affect reproductive development in the male rat. However, the thyroid axis is significantly altered. In addition to alterations in thyroid hormones, thyroid histological changes are also a good indicator of altered thyroid homeostasis or hypothyroidism.
Short-term administration of potassium perchlorate in association with methimazole appears to be effective in rapidly controlling thyrotoxicosis. However, due to potential toxicity of potassium perchlorate, its use should be reserved for severe cases and careful monitoring of potential side effects should be carried out
In a human study was found that changes in serum thyroid hormone levels may not be spontaneous but related to potassium perchlorate treatment as hypothyroidism developed again after potassium perchlorate was withdrawn. Potassium perchlorate was well tolerated in most patients however it is not recommended as the first-line treatment due to potential toxicity.
In a human study it was found that a 6 month exposure to perchlorate at doses up to 3 mg/day had no effect on thyroid function, including inhibition of thyroid iodide uptake as well as serum levels of thyroid hormones TSH and Tg.
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