Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 231-912-9 | CAS number: 7778-74-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Toxicokinetic data are taken from published authoritative reviews and published data
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - inhalation (%):
- 100
Additional information
Short-term studies on humans and animals demonstrate that perchlorate appears to be readily absorbed by the digestive system after oral exposure. Maximum blood levels appear within a few hours after ingestion. Data also suggest the absorption of inhaled perchlorate but dermal absorption is likley to be very low. Perchlorate is rapidly taken up into the thyroid gland, by an active transport mechanism (displacing iodide), and reaches a maximum level in the thyroid in approximately 4 hours in rats. Elimination of perchlorate from the thyroid is also rapid; half-lives of 10–20 hours have been estimated in rats. Perchlorate does not appear to be modified in the body, either by degradation or covalent binding. Perchlorate is rapidly eliminated from the body in the urine with half-lives of approximately 8–12 hours in humans and 10– 20 hours in rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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