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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Developmental toxicity / teratogenicity

Currently viewing:

Administrative data

developmental toxicity
Type of information:
Adequacy of study:
supporting study
Study period:
Rationale for reliability incl. deficiencies:
other: Short description on comprehensive studies available via the internet by US EPA and

Data source

Reference Type:
secondary source
lactofen - Compound Summary (CID 62276)
US EPA and Pubchem NCBI
Bibliographic source:,3,31,7,12,25:p3_xchemical_id:2666

Materials and methods

Principles of method if other than guideline:
Teratology studies; no further data

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
Cas Number:
Molecular formula:
Details on test material:
No data

Test animals

other: rabbits and rats
not specified

Administration / exposure

not specified
Details on mating procedure:
No data
Duration of treatment / exposure:
No data
Frequency of treatment:
Duration of test:
no data
No. of animals per sex per dose:
no data

Results and discussion

Results (fetuses)

Fetal abnormalities

not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

Executive summary is derived from the following internet links on 2012 -11 -09.

References of individual studies:

PPG Industries. 1983a. MRID No. 00132885. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

PPG Industries. 1982b. MRID No. 00117566. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

PPG Industries. 1985c. MRID No. 00150367, 00163307. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

2-Generation Reproduction - rat: Reproductive NOEL=50 ppm (2.5 mg/kg/day); Reproductive LEL=500 ppm (25 mg/kg/day) (reduced mean pup weight, increased relative and absolute weight of brain, heart, liver, spleen and testes; brown pigment in liver; extramedullary hematopoeisis, hyperplasia of spleen); core grade minimum (PPG Industries, 1983a)

Teratology - rat: Fetotoxic NOEL=50 mg/kg/day; Fetotoxic LEL=150 mg/kg (bent ribs); Teratogenic NOEL=150 mg/kg/day; Maternal NOEL=50 mg/kg/day; Maternal LEL=150 mg/kg/day (post implantation loss; reduced body weight); core grade minimum (PPG Industries, 1982b)

Teratology - rabbit: Maternal NOEL=4 mg/kg/day; Maternal LEL=20 mg/kg/day (decreased food consumption); Fetotoxic NOEL=20 mg/kg/day; core grade minimum (PPG Industries, 1985c)