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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 - 10 Aug 1983
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Version / remarks:
EEC Directive 79/831
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
not specified
Radiolabelling:
no
Analytical monitoring:
yes
Details on sampling:
HPLC / UV-VIS
Buffers:
pH 4,0: 1,00 ml 0,1 N NaOH +12 5 ml potassiumbiphtalate 0,1 M to 250 ml with water.
pH 7,0: 74,1 ml 0,1 N NaOH + 12 5 ml monopotassiumphosphate 0,1 M to 250 ml with water.
pH 9,0: 53,25 ml 0,1 N NaOH +125 ml boric acid 0,1 M in KCl 0,1 M to 250 ml with water.
Details on test conditions:
Hydrolysis of the active ingredient at 50°C and pH 4.0, 7.0 and 9.0. Determination of the residual Azo Yellow by high pressure liquid chromatography using a external standard.
Duration:
5 d
pH:
4
Temp.:
50 °C
Initial conc. measured:
0.008 mol/L
Duration:
5 d
pH:
7
Temp.:
50 °C
Initial conc. measured:
0.008 mol/L
Duration:
5 d
pH:
9
Temp.:
50 °C
Initial conc. measured:
0.008 mol/L
Number of replicates:
1
Positive controls:
no
Negative controls:
yes
Preliminary study:
Substance is hydrolytically stable at all tested pH values.
Transformation products:
not measured
% Recovery:
98.9
pH:
4
Temp.:
50 °C
Duration:
5 d
% Recovery:
98.8
pH:
7
Temp.:
50 °C
Duration:
5 d
% Recovery:
99.3
pH:
9
Temp.:
50 °C
Duration:
5 d
Key result
pH:
4
Temp.:
20 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
7
Temp.:
20 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
hydrolytically stable based on preliminary test
Key result
pH:
9
Temp.:
20 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
hydrolytically stable based on preliminary test
Validity criteria fulfilled:
yes
Conclusions:
The test item is hydrolytically stable at the examined pH values 4, 7, 9 and 50°C. It has a half-time longer than one year at 50°C (and 20°C).

Description of key information

The test item is hydrolytically stable at the examined pH values 4, 7, 9 and 50°C (preliminary test, 5 d). It has a half-time longer than one year at 50°C (and 20°C).

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
20 °C

Additional information