Pentene

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 November to 1 December 1992

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.2 (Acute Toxicity (Inhalation))

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OTS 798.1150 (Acute inhalation toxicity)

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Pentene

EC Number:

246-916-6

EC Name:

Pentene

Cas Number:

25377-72-4

Molecular formula:

C5H10

IUPAC Name:

pent-1-ene

Details on test material:

- Name of test material (as cited in study report): pentene-1

- Physical state: A clear colourless liquid

- Analytical purity: 98.4%.

- Lot/batch No.: T1814.

- Storage condition of test material: at 4ºC in the dark under nitrogen and in the original container.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Analytical verification of test atmosphere concentrations:

yes

Remarks:

GC

Duration of exposure:

4

Remarks on duration:

Observation period of 14 days

Concentrations:

19.6 mg/l of air.

No. of animals per sex per dose:

5 per sex per group.

Control animals:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 19.6 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: No death observed.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

There were no deaths in a group of rats exposed to pentene-1 at a concentration in air of 19.6 mg/l. Pentene-1 is biologically inert in terms of acute lethality.

Executive summary:

Acute inhalation study was conducted in rats (substance as vapour) with 4 -hour exposure period. There were no deaths in a group of rats exposed to pentene-1 at a concentration in air of 19.6 mg/l. Pentene-1 is biologically inert in terms of acute lethality. LD 50 of the substance is expected to be greater than 19.6 mg/l.

The test material does not meet the criteria for classification according to EU classification system (Council Directive 67/548/EEC and Regulation (EC) No 1272/2008).

The test was conducted at the GLP facility in accordance with test guidelines, therefore a reliability of 1 is assigned to the data.