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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
3 November to 8 December 1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 (Acute Toxicity (Oral))
Version / remarks:
(Annex V, 1984)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
(Date of inspection: 17 August 1992 Date of Signature: 30 October 1992)
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentene
EC Number:
246-916-6
EC Name:
Pentene
Cas Number:
25377-72-4
Molecular formula:
C5H10
IUPAC Name:
pent-1-ene
Details on test material:
- Name of test material (as cited in study report): pentene-1.

- Physical state: clear colourless liquid.

- Analytical purity: 98.4.

- Impurities (identity and concentrations): n-pentane + iso-pentane 0.33%, 2-MB-1 + 2-MB-2 0.93%, cis + trans pentene-2 0.1%, other unsaturated C5-hydrocarbons 0.13%, non-volatile residue 0.001%.

- Purity test date: 29 September 1992.

- Lot/batch No.: ST92/336

- Storage condition of test material: Stored in the dark at between 0 and 5ºC.

Test animals

Species:
rat
Strain:
other: Crj: CD(BR)
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Doses:
3200, 4000 and 5000 mg/kg
(Preliminary study; 4000 mg/kg)
No. of animals per sex per dose:
5 animals per sex
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
5 059 mg/kg bw
Based on:
test mat.
95% CL:
4 012 - 8 000
Sex:
female
Dose descriptor:
LD50
Effect level:
4 965 mg/kg bw
Based on:
test mat.
95% CL:
4 438 - 6 055
Sex:
male/female
Dose descriptor:
LD50
Effect level:
4 937 mg/kg bw
Based on:
test mat.
95% CL:
4 406 - 7 330

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 of pentene-1 in fasted rats was 4937 mg/kg (95% confidence interval 4406 to 7330 mg/kg) for males and females.
Executive summary:

The acute oral LD50 of pentene-1 in fasted rats was 4937 mg/kg (95% confidence interval 4406 to 7330 mg/kg). The test material was

dispersed in corn oil and administered by oral gavage at 10 ml/kg. Groups of five male and five female rats were dose at 3200. 4000 and 5000 mg/kg.

The test material does not meet the criteria for classification according to EU classification system (Council Directive 67/548/EEC and Regulation (EC) No 1272/2008).

The stuyd was conducted at a GLP facility in accordance with a validated test guideline, therefore a reliability of 1 is assigned.