Registration Dossier
Registration Dossier
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EC number: 224-169-7 | CAS number: 4223-03-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Skin penetration has been shown to be extremely low ca. 0.3% in rats and lower than this with human skin. Based on the recovery of ca.90% from the study using none labeled test substance a worst case absorption could be considered to be 10%. In the absence of any data on oral and inhalation exposure, these are both assumed to be 100%. No specific metabolism data are available, only information from the OECD Toolbox.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 0.3
- Absorption rate - inhalation (%):
- 100
Additional information
The in-vitro skin penetration data indicates a very low /slow penetration for human skin of significantly less than the rat skin which showed 0.3% in 24 hours. We have no information on absorption via the gastrointestinal tract or via the lungs after inhalation, therefore the ECHA defaults are quoted of 50% absorption via the gastrointestinal tract and 100% absorption in the lungs after inhalation.
CAS 4223-03-4 has no data in the QSAR (OECD) Toolbox.
For the evaluation the structure was considered to be: C(=O)(C=C)NC(C)(C)CC(C)(C)C
The various metabolism/transformations:
No information from observed metabolism.
Simulators:
- Autoxidation: 0 metabolites
- Dissociation: : 0 metabolites
- Hydrolysis: (acidic & basic conditions) yes, forming of the branched C8-amine and acrylic acid
- Skin metabolism: 2 metabolites: being the two hydrolysis products
- Rat liver S9 metabolism: 7 metabolites. (See: OECD Toolbox - chemicals list S9-simulator.pdf) (For it looks like various possible oxidations, including one epoxide from the acrylic part)
Otherwise, being an acrylic acid compound, one can expect the various messages regarding possible protein and DNA reactivity in the profile. However the lack of evidence for genotoxicty or skin sensitization does not indicate any significant reaction with proteins or DAN that results in any toxic effects.
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