Registration Dossier
Registration Dossier
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EC number: 235-185-9 | CAS number: 12125-01-8
Endpoint summary
Administrative data
Description of key information
Fluoride salts are not considered irritants to the skin based on results of rabbit skin but are considered irritants to the eye based on a primary eye irritation test.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In rabbits (Allied Corp., 1983), no signs of skin corrosion or skin irritation (erythema and/or edema) were observed after a 4-hour topical (occluded) exposure to potassium bifluoride. The skin was observed and scored for signs of irritation/corrosion immediately after patch removal and again at 48 hours after patch removal.
In a rabbit eye irritation test (Wnorowski, 1995), 0.1 gram of Composite NaF was instilled in the right eye of each rabbit. The left eye remained untreated and served as a control. Occular irritation was evaluated by the method of Draize et al. The eye scores were further classified by the system of Kay and Calandra. Twenty four hours after test substance instillation, all treated eyes exhibited conjunctivis. All six unwashed eyes also had corneal opacity and iritis.
Effects on eye irritation: irritating
Justification for classification or non-classification
Based on the skin irritation test, classification is not required for Ammonium fluoride.
Based on the results of the primary eye irritation test, and according to the CLP regulation (EC) 1272 -2008, Ammonium fluoride is classified as: - Eye damage category 1
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