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Difluoro [1,1,2,2-tetrafluoro-2-(pentafluoro-ethoxy)] ethoxy acetic acid (EEA) in the vehicle, sterile water for injection, was administered intravenously once to 1 pharmacokintic (blood collection) and 1 excretion group of Crl:CD(SD) rats (WIL Research Laboratories, LCC, 2007). The dosage level was 10 mg/kg bw for both groups at a dosage volume of 5 mL/kg. The pharmacokinetic group consisted of 9 animals/sex and the excretion group consisted of 3 animals/sex.

Systemic exposure (AUC0-∞) to EEA for male rats was almost 7-fold higher than for female rats following a single intravenous dose of EEA at 10 mg/kg bw. EEA in the serum cleared more rapidly in the male rats than in the female rats, and the female rats had a greater volume distribution than the male rats. EEA cleared in the urine more rapidly in the female rats than in the male rats, but most of the EEA dose was eliminated over 12 hours post-dosing in both genders. The elimination of EEA in the urine appeared to be mono-exponential for male rats and appeared not to be log-linear for female rats.

 

Difluoro [1,1,2,2–tetrafluoro–2–(pentafluoro-ethoxy)] ethoxy acetic acid (EEA) in the vehicle, sterile water, was administered intravenously once to 1 group (Group 1) of Cynomolgus monkeys (WIL Research Laboratories, LCC, 2007). The dosage level was 10 mg/kg bw at a dosage volume of 5 mL/kg. Group 1 consisted of 3 males and 3 females. Pharmacokinetic parameters for EEA in serum were generally similar between the genders. On average, about 60-65% of the administered dose of EEA was recovered in the urine during the 7 days post-dosing.