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EC number: 700-323-3 | CAS number: 908020-52-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Difluoro [1,1,2,2-tetrafluoro-2-(pentafluoro-ethoxy)] ethoxy acetic acid (EEA) in the vehicle, sterile water for injection, was administered intravenously once to 1 pharmacokintic (blood collection) and 1 excretion group of Crl:CD(SD) rats (WIL Research Laboratories, LCC, 2007). The dosage level was 10 mg/kg bw for both groups at a dosage volume of 5 mL/kg. The pharmacokinetic group consisted of 9 animals/sex and the excretion group consisted of 3 animals/sex.
Systemic exposure (AUC0-∞) to EEA for male rats was almost 7-fold higher than for female rats following a single intravenous dose of EEA at 10 mg/kg bw. EEA in the serum cleared more rapidly in the male rats than in the female rats, and the female rats had a greater volume distribution than the male rats. EEA cleared in the urine more rapidly in the female rats than in the male rats, but most of the EEA dose was eliminated over 12 hours post-dosing in both genders. The elimination of EEA in the urine appeared to be mono-exponential for male rats and appeared not to be log-linear for female rats.
Difluoro [1,1,2,2–tetrafluoro–2–(pentafluoro-ethoxy)] ethoxy acetic acid (EEA) in the vehicle, sterile water, was administered intravenously once to 1 group (Group 1) of Cynomolgus monkeys (WIL Research Laboratories, LCC, 2007). The dosage level was 10 mg/kg bw at a dosage volume of 5 mL/kg. Group 1 consisted of 3 males and 3 females. Pharmacokinetic parameters for EEA in serum were generally similar between the genders. On average, about 60-65% of the administered dose of EEA was recovered in the urine during the 7 days post-dosing.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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