Registration Dossier
Registration Dossier
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EC number: 500-058-1 | CAS number: 27252-75-1 1 - 2.5 moles ethoxylated
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10-17 Feb 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
- GLP compliance:
- no
- Type of method:
- slow-stirring method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Octan-1-ol, ethoxylated
- EC Number:
- 500-058-1
- EC Name:
- Octan-1-ol, ethoxylated
- Cas Number:
- 27252-75-1
- Molecular formula:
- C10H22O2
- IUPAC Name:
- Octan-1-ol, ethoxylated
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 2.19
- Temp.:
- 25 °C
- pH:
- >= 4.42 - <= 4.58
- Remarks on result:
- other: std. dev. 0.003
Any other information on results incl. tables
The concentration of the test item in the aqueous and 1 -octanol phase was determined after 48, 50, 52 and 54 hours, ensuring that an equilibrium concentration was established in both phases. At each test time, three different test solutions were analysed. The results are given in the table:
Time (h) |
Octanol phases, test mixture (mg/g) |
Aqueous phases, test mixture (mg/g) |
||||
1 |
2 |
3 |
1 |
2 |
3 |
|
48 |
19.09 |
18.96 |
19.14 |
0.1232 |
0.1230 |
0.1239 |
50 |
19.02 |
19.10 |
19.05 |
0.1224 |
0.1229 |
0.1232 |
52 |
18.94 |
18.89 |
19.08 |
0.1233 |
0.1215 |
0.1228 |
54 |
18.87 |
19.14 |
19.14 |
0.1230 |
0.1221 |
0.1228 |
For each time interval the Pow and log Pow values are calculated for each test mixture. The results are summarized in the table:
Time (h) |
Calculated Pow values, test mixture |
Calculated log Pow values, test mixture |
||||
1 |
2 |
3 |
1 |
2 |
3 |
|
48 |
155.0 |
154.1 |
154.5 |
2.190 |
2.188 |
2.189 |
50 |
155.4 |
155.4 |
154.6 |
2.191 |
2.191 |
2.189 |
52 |
153.6 |
155.5 |
155.4 |
2.186 |
2.192 |
2.191 |
54 |
153.4 |
156.8 |
155.9 |
2.186 |
2.195 |
2.193 |
pH values of aqueous phases were 4.51, 4.42 and 4.58, for mixtures 1, 2 and 3, respectively.
Applicant's summary and conclusion
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