Registration Dossier
Registration Dossier
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EC number: 944-574-9 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
The partition coefficient of the test item was determined to be 1.00 x 10E10 with a Log10 Pow value > 10.0 (OECD 117 and EU Method A.8).
Key value for chemical safety assessment
Additional information
GUIDELINE
The determination was carried out using the HPLC Method and a procedure designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
METHOD
The test system consisted of a high performance liquid chromatograph with appropriate detectors. A reverse phase HPLC column with a very low percentage of polar groups was used.
DISCUSSION
As the test item was a mixture and the result was expected to be high, it was concluded that the HPLC method would be the most suitable for determination of partition coefficient. The test was modified from that stated in the guidelines to allow assessment of the partition coefficient up to a value of log10 Pow 10.0 by the use of additional reference standards.The pH of the mobile phase was unadjusted so that the test item was tested in its non-ionised form.
CONCLUSION
The partition coefficient of the test item was determined to be 1.00 x 10E10 with a Log10 Pow value > 10.0.
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