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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data is from secondary safety data sheet .

Data source

Reference
Reference Type:
secondary source
Title:
Safety data sheet
Author:
Safety data sheet-TAKASAGO
Year:
2015
Bibliographic source:
Safety data sheet-TAKASAGO-Revision No: 1, Revision Date: 27 May 2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
The skin sensitization study of 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- was conducted in guinea pigs to determine its sensitization potential.
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Reference substance name:
2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
IUPAC Name:
2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
Constituent 2
Chemical structure
Reference substance name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
EC Number:
248-907-2
EC Name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Cas Number:
28219-60-5
Molecular formula:
C13H22O
IUPAC Name:
2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
Details on test material:
- Name of test material (as cited in study report): 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- Molecular formula : C13H22O
- Molecular weight : 194.316 g/mol
- Substance type: organic
- Physical state: liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No Data Available

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other:
Vehicle:
other: Ethanol
Concentration / amount:
30% in ethanol
Challenge
Concentration / amount:
30% in ethanol
No. of animals per dose:
No Data Available
Details on study design:
No Data Available
Challenge controls:
No Data Available
Positive control substance(s):
not specified

Results and discussion

Positive control results:
No Data Available

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
30% in ethanol
No. with + reactions:
0
Clinical observations:
not sensitising
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 30% in ethanol. No with. + reactions: 0.0. Clinical observations: not sensitising.

Any other information on results incl. tables

No Data Available

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Conclusions:
The test material 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- (CAS No: - 28219-60-5) was observed to be not sensitizing to guinea pigs.
Executive summary:

The skin sensitization study of 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)- (CAS No: -28219-60-5) was performed in guinea pigs to observed its sensitizing efficacy by Guinea pig maximization test.

 

The test sample was applied at concentration of 30% in ethanol.

 

Since no skin reactions were observed, the test chemical 2-Buten-1-ol, 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopenten-1-yl) - (CAS No: -28219-60-5) was found to be non sensitizing in guinea pigs.