Registration Dossier
Registration Dossier
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EC number: 248-907-2 | CAS number: 28219-60-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: data from safety data sheets
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Safety data sheet
- Author:
- TAKASAGO
- Year:
- 2 015
- Bibliographic source:
- Safety data sheet-TAKASAGO-Revision No: 1, Revision Date: 27 May 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As given below
- Principles of method if other than guideline:
- The skin irritation study of2-Buten-1-ol, 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopenten-1-yl)- was conducted in guinea pigs to determine its irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
- IUPAC Name:
- 2-Buten-1-ol, 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-
- Reference substance name:
- 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- EC Number:
- 248-907-2
- EC Name:
- 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- Cas Number:
- 28219-60-5
- Molecular formula:
- C13H22O
- IUPAC Name:
- 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material : 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- Molecular formula : C13H22O
- Molecular weight : 194.316 g/mol
- Smiles notation : C1(C(=CC[C@@H]1C\C=C(\CO)C)C)(C)C
- Substance type: organic
- Physical state: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No Data Available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 0.5% in petrolatum
- Duration of treatment / exposure:
- 48 hours
- Observation period:
- No Data Available
- Number of animals:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Remarks on result:
- other: Non irritant
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Conclusions:
- The test material 2-Buten-1-ol, 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopenten-1-yl) - (CAS No: - 28219-60-5) was observed to be not irritating to
guinea pigs. - Executive summary:
The skin irritation study of 2-Buten-1-ol, 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopenten-1-yl) - (CAS No: -28219-60-5) was performed in guinea pigs to observe its irritation efficacy. The test sample was applied at concentration of 0.5% in petrolatum under 48 hours closed patch.Since no known skin reactions were noted, the test chemical 2-Buten-1-ol, 2-methyl-4-(2, 2, 3-trimethyl-3-cyclopenten-1-yl) - (CAS No: -28219-60-5) reported to be non irritant in guinea pigs.
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