2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from peer-reviewed journal

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Fragrance raw materials monographs: α-Santalol

Author:

Opdyke

Year:

1974

Bibliographic source:

Food and Cosmetics Toxicology, Volume 12, Issues 7–8, December 1974, Pages 991-992

Reference 2

Reference Type:

secondary source

Title:

Scientific Literature Review of Alicyclic Compounds of Carbon, Hydrogen and Oxygen in Flavor Usage

Author:

Flavor and Extract Manufacturers' Association

Year:

1985

Bibliographic source:

National Technical Information Service, Volume I, 1-648, 1985

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as below

Principles of method if other than guideline:

Acute oral toxicity of α-Santalol in rats

GLP compliance:

not specified

Test type:

other: No data

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

5-(2,3-dimethyltricyclo[2.2.1.02,6]hept-3-yl)-2-methylpent-2-en-1-ol, stereoisomer

EC Number:

204-102-8

EC Name:

5-(2,3-dimethyltricyclo[2.2.1.02,6]hept-3-yl)-2-methylpent-2-en-1-ol, stereoisomer

Cas Number:

115-71-9

IUPAC Name:

5-(2,3-dimethyltricyclo[2.2.1.0~2,6~]hept-3-yl)-2-methylpent-2-en-1-ol

Constituent 2

Reference substance name:

α-Santalol

IUPAC Name:

α-Santalol

Constituent 3

Reference substance name:

[1S-[1α,2α(Z),4α]]-2-methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)-2-penten-1-ol

EC Number:

201-027-2

EC Name:

[1S-[1α,2α(Z),4α]]-2-methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)-2-penten-1-ol

Cas Number:

77-42-9

IUPAC Name:

2-methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)pent-2-en-1-ol

Test material form:

liquid: viscous

Details on test material:

- Name of test material (as cited in study report): α-Santalol
- Molecular formula (if other than submission substance): C15H24O
- Molecular weight (if other than submission substance): 220.3536 g/mole
- Substance type: Organic
- Physical state: Almost colorless, viscous liquid; sweet, woody odor (ARC)

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

No data available

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

No data available

Doses:

3800 mg/kg bw

No. of animals per sex per dose:

No data available

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

Statistics:

No data available

Results and discussion

Preliminary study:

No data available

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

3 800 mg/kg bw

95% CL:

3 060 - 4 710

Remarks on result:

other: 50 % mortality observed

Mortality:

50 % mortality observed in treated male and female rats.

Clinical signs:

other: No data available

Gross pathology:

No data available

Other findings:

No data available

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Conclusions:

LD50 was considered to be 3800 mg/kg bw (3060 – 4710 mg/kg bw ) when male and female rats were treated with α-Santalol orally.

Executive summary:

In a acute oral toxicity study,male and female rats were treated with α-Santalol in the concentration of3800 mg/kg bw orally and observed for 14 days. 50 % mortality observed in treated male and female rats. LD50 was considered to be 3800 mg/kg bw( 3060 – 4710 mg/kg bw) when male and female rats were treated with α-Santalol orally.