Registration Dossier
Registration Dossier
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EC number: 248-907-2 | CAS number: 28219-60-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: data from safety data sheets
Data source
Reference
- Reference Type:
- secondary source
- Title:
- SANTALIFF BHT
- Author:
- INTERNATIONAL FLAVORS & FRAGRANCES
- Year:
- 2 011
- Bibliographic source:
- Material Safety Data Sheet, INTERNATIONAL FLAVORS & FRAGRANCES, 02/14/2011
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the ocular irritation potential of the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- EC Number:
- 248-907-2
- EC Name:
- 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- Cas Number:
- 28219-60-5
- Molecular formula:
- C13H22O
- IUPAC Name:
- 2-methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)-2-buten-1-ol
- Reference substance name:
- 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol
- IUPAC Name:
- 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol
- Test material form:
- other: liquid
- Details on test material:
- Name of test material (as cited in study report): 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol
Molecular formula:C13H22O
Molecular weight :194.316 g/mol
SMILES: OCC(=CCC(C(C(=C1)C)(C)C)C1)C
Substance type: Organic
Physical state: Liquid
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- undiluted test sample
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: no data
- Remarks on result:
- other: moderate irritation observed
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Conclusions:
- An eye irritation study in rabbits was performed in rabbits. 2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol was considered to be moderately irritating to rabbit eyes.
- Executive summary:
An eye irritation study in rabbits was performed in rabbits. Undiluted test sample was instilled into rabbit eyes. Effects were observed.2-Methyl-4-(2,2,3-trimethyl-3-cyclopenten-1-yl)but-2-en-1-ol was considered to be moderately irritating to rabbit eyes.
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