Registration Dossier
Registration Dossier
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EC number: 619-590-1 | CAS number: 135302-13-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 3-methoxy-4-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one
- EC Number:
- 619-590-1
- Cas Number:
- 135302-13-5
- Molecular formula:
- C4H7N3O2
- IUPAC Name:
- 3-methoxy-4-methyl-4,5-dihydro-1H-1,2,4-triazol-5-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Cremophor EL 2% (v/v)
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- three male rats, three female rats
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
Any other information on results incl. tables
A dose of 2,000 mg/kg body weight was tolerated by male and female rats without mortalities, clinical signs, effects on weight development and gross pathological findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based on the present investigations, the test substance is therefore to be regarded as relatively non-toxic and not to be classified according to Guideline 79/831/EEC.
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