Registration Dossier
Registration Dossier
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EC number: 223-786-9 | CAS number: 4073-98-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Acutely toxic for aquatic algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 6.104 mg/L
- EC10 or NOEC for freshwater algae:
- 0.26 mg/L
Additional information
No experimental data are available for 4,4'-methylenebis(2,6-xylidine) (CAS 4073 -98 -7). To assess the toxicity to aquatic algae, read across was made to the analogue substance 4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0).
A study following the German Industrial Standard DIN 38412, part 9 was performed by BASF to test the toxicity of 4,4'-methylenebis(2-methylaniline) to Desmodesmus subspicatus. The study was statistically re-evaluated using the program ToxRatPro (v2.10) and is considered valid. Based on growth rate, the 72 -h EC50 and the 72 -h EC10 are 6.104 mg/L and 0.260 mg/L, respectively. The 72 -h NOEC was determined to be < 0.020 mg/L (BASF AG, 1988, project no.: 2/0248/88).
Based on these results, the test substance is expected to be acutely toxic to aquatic algae.
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