Registration Dossier
Registration Dossier
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EC number: 223-786-9 | CAS number: 4073-98-7
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
No experimental data are available for 4,4'-methylenebis(2,6-xylidine) (CAS 4073 -98 -7). To assess the toxicity to fish, read across was made to the analogue substances 4,4'-methylenebis(2-methylaniline) (CAS 838 -88 -0) and N,N,N',N'-tetramethyl-4,4'-methylenedianiline(CAS 101 -61 -1).
The toxicity of 4,4'-methylenebis(2 -methylaniline) (CAS 828 -88 -0) was tested with Leuciscus idus according to the German Industrial Standard DIN 38412, part 15. No toxicity was observed up to the water solubility of 16 mg/L. Based on nominal concentrations and the geometric mean of the LC0 (464 mg/L) and LC100 (1000 mg/L), the observed 96-h LC50 was 681 mg/L (BASF AG, 1989; report No. 10F0344/885232).
In addition N,N,N',N'-tetramethyl-4,4'-methylenedianiline (CAS 101 -61 -1) was tested according to OECD 203 (Fish, Acute Toxicity Test) with Danio rerio (reported as Brachydanio rerio). The tested substance was sparingly soluble. Up to 72 hours after study start undissolved test substance was visible in all concentrations on the bottom and at the water surface and the aqueous phase showed a turbidity. After 96 hours undissolved test substance was visible in all concentrations only on the bottom, increasing with the concentrations. No mortality occured up to the nominal concentration 100 mg/L and no other substance-related effects were observed. Based on nominal concentrations, the observed 96 -h LC50 was > 100 mg/L (BASF AG, 1999, 17F0289/985096).
Following this, the test substance is assessed to be with high probability acutely not harmful to fish.
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