N,N-dimethyldecylamine N-oxide

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

The amine oxides were synthesised by oxidation of the corresponding trialkylamine with H2O2. After oxidation and isolation the products were thoroughly dried by azeotropic distillation with benzene and toluene followed by multiple crystallisations (4-5 times) from dry Me2CO and dried over P4O10 in a high vacuum. The purity was checked by TLC and IR spectra.

GLP compliance:

no

Type of method:

other: method not specified, however a capllary method was used for shorter chain length amine oxides

Melting / freezing pt.:

133 - 136 °C

Atm. press.:

1 013 hPa

Remarks on result:

other: C10 AO

Melting / freezing pt.:

130 - 134 °C

Atm. press.:

1 013 hPa

Remarks on result:

other: C12 AO

Melting / freezing pt.:

125 - 129 °C

Atm. press.:

1 013 hPa

Remarks on result:

other: C14 AO

Melting / freezing pt.:

126 - 130 °C

Atm. press.:

1 013 hPa

Remarks on result:

other: C16 AO

A study is described in the literature [Devinsky et al 1985] where the authors measured the melting points of the pure alkyl dimethylamine oxide constituents of the substance. The melting points ranged from 126-130 °C for C16 amine oxide to 133-136 °C for C10 amine oxide. Based on these values the melting point of the substance is expected to be in the range of 125 -136 °C. The measured melting point for C10 amine oxide was 133 - 136°C.

Conclusions:

Based on the experimental melting points of the different alkyl chain length components, the melting point of the substance is approximately 133 -136

Description of key information

The melting point is in the range of 133-136 °C

Additional information

A study is described in the literature [Devinsky et al 1985] where the authors measured the melting points of a range of single chain length alkyl dimethylamine oxides. The measured melting point range for C10 AO was 133 - 136°C.