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EC number: 220-020-5
CAS number: 2605-79-0
In an in vitro skin corrosivity study performed in accordance with OECD
Guideline 431 using the EST-100 model the test item,
N,N-dimethyldecylamine-N-oxide (solution), was applied to the skin
surface. De-ionised water was used as the negative control. 8 N KOH was
used as the positive reference item. Two
exposure times of 3 minutes or 1 hour were employed.
In comparison to the negative controls, the mean viability of cells
exposed to the test item was 78.8% after a 3-minute exposure period and
65.9% after a 1-hour exposure. The OD540values
were well above the cut-off percentage cell viability
values distinguishing corrosive from non-corrosive test items of <50% or<15%
for a 3-minute or 1-hour treatment, respectively. Therefore, the test
item was non-corrosive in this skin model and is predicted to be
non-corrosive to human skin.
The mean viability of cells treated with the positive reference item 8 N
KOH were 5.0% (3-minute incubation) and 1.2% (1-hour incubation) of the
negative controls and were below the cut-off values. Hence, 8 N KOH
caused pronounced corrosion in this skin model and is predicted to be
corrosive to human skin.
Under the present test conditions N,N-dimethyldecylamine-N-oxide
(solution) tested at two exposure
times of 3 minutes or 1 hour was non-corrosive to skin in
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