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EC number: 220-020-5
CAS number: 2605-79-0
Table 1: HET-CAM Mean Irritation Scores (IS)
Effect according to scoring scheme for irritation testing
Irritation Score (IS)
Negative control (0.9% NaCl soln)
Positive control (0.1 N NaOH)
Positive control (1% SDS)
SD: standard deviation
1% SDS: 1% aqueous sodium dodecyl sulfate
Three eggs each were
treated with 0.3 mL C10 AO solution/egg and with the control
items. 0.9% NaCl solution was used as the negative control
item. 0.1 N Sodium
hydroxide (NaOH) or 1% aqueous
sodium dodecyl sulphate (SDS) were used as the positive
control items. The administration volume for the control items
was 0.3 mL per egg. After
administration of the test item blood vessels including the capillary
system and the albumen were examined and scored for irritant effects
(haemorrhage, coagulation and lysis) during 5 minutes. The eggs
treated with C10 AO solution revealed an effect with an irritation score
(IS) of 16.3. The test item was considered to be a strong irritant.
control items 0.1
N NaOH or 1% SDS caused the expected effect with irritation scores (IS)
of 17.7 or 10.0, respectively and,
hence, were well within the historical data-range.No
effects were observed in the negative control 0.9%
HET-CAM assay is considered to be valid.
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