Registration Dossier
Registration Dossier
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EC number: 203-187-9 | CAS number: 104-23-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
Data source
Referenceopen allclose all
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
- Reference Type:
- other: Authoritative database
- Title:
- Toxicity of test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS Substance Database
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity of test chemical in rat.
- GLP compliance:
- not specified
- Test type:
- other: Not specified
- Limit test:
- no
Test material
- Reference substance name:
- Dapsone
- EC Number:
- 201-248-4
- EC Name:
- Dapsone
- Cas Number:
- 80-08-0
- Molecular formula:
- C12H12N2O2S
- IUPAC Name:
- 4,4'-Diaminodiphenyl Sulphone
- Test material form:
- solid
- Details on test material:
- - IUPAC Name: 4,4'-diamino diphenyl sulfone
- InChI: 1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
- Smiles: S(c1ccc(N)cc1)(c1ccc(N)cc1)(=O)=Ow
- Common name:Dapsone
- Molecular formula :C12H12N2O2S
- Molecular weight:248.305 g/mol
- Substance type:Organic
- Physical state:Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- Not specified
- Doses:
- 1000 mg/kg bw
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- Not specified
- Statistics:
- Not specified
Results and discussion
- Preliminary study:
- Not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality observed
- Mortality:
- 50% mortality observed at a dose of 1000 mg/kg bw
- Clinical signs:
- other: Not specified
- Gross pathology:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 value was considered to be 1000 mg/kg bw, when rats were treated with test chemical via oral route
- Executive summary:
Acute oral toxicity study of test chemical was conducted on rats at the dose concentration of 1000 mg/kg bw. The test chemical was administered via oral route. All animals were maintained under close observation for recording toxic signs and time of death . Therefore, LD50 value was considered to be 1000 mg/kg bw, when rats were treated with test chemical via oral route.
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