Registration Dossier
Registration Dossier
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EC number: 236-690-7 | CAS number: 13464-97-6
Endpoint summary
Administrative data
Description of key information
Additional information
Only one study has evaluated the bioaccumulation potential of hydrazine in fish. Slonim and Gisclard (1976) exposed guppies to hydrazine dissolved in hard (420 mg/l as CaCO3) or in soft (24 mg/l as CaCO3) water. Laboratory tests lasted 4 days and used concentrations of 0.5 mg/l and 0.25 mg/l for hard and soft waters, respectively. No bioconcentration was observed in softwater exposures because of analytical limitations, whereas bioconcentration occurred in hardwater. A Bioconcentration Factor (BCF) of 288 l/kg was derived from the hydrazine concentration measured in guppies after 4 days in contaminated hardwater, (144 mg/kg) and the aqueous concentration of hydrazine of 0.5 mg/l. The resulting BCF may somewhat underestimate bioconcentration because the hydrazine level of 0.5 mg/l is high enough to generate ecotoxicity. In addition, it is not known if steady-state was reached between fish and the surrounding medium.
Considering the low empirical BCF obtained for guppy, experimental evidence for metabolic transformation, high miscibility in water and the low log KOW, it is proposed that hydrazine mono-nitrate does not significantly bioaccumulate in fish.
Reference
Slonim AR and Gisclard JB (1976) Hydrazine degradation in aquatic systems.Bulletin of Environmental Contamination and Toxicology, 1(16), 301–309. [Cited in Choudhary G and Hansen H (1998) Human health perspective on environmental exposure to hydrazines: a review.Chemosphere,37(5), 801–843.].
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