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EC number: -
CAS number: -
The LC 0 was equal or greater than 243 mg/kg.
Camphene was given by inhalation to male rabbits that were
anesthetized with urethane (ethyl carbamate) for 24 hours and were
arranged for collection of respiratory tract fluid. Test substance was
dissolved in 1 mL of ethanol in amounts of 1, 3, 9, 27, 81, and 243 mg.
Each dose was given to 4 to 6 rabbits. Respiratory tract fluid
was collected for a control period of two to four hours. The collecting
tube was then replaced by a cleaned, empty tube, test item added to the
vaporizer, and respiratory tract fluid collected for a subsequent period
of four to six hours. Steam generated by the water vaporizer volatilized
the test item which was carried to the conditioned air reservoir from
which it was inhaled by each anesthetized rabbit. Inhalation of
camphene by urethanized rabbits in doses 3-27 mg/kg produced significant
increase in volume output of respiratory tract fluid, accompanied by
decrease in specific gravity and increase in total solids.
Dose-dependent increase in volume output of respiratory tract fluid
varied with the season. The expectorant action began to disappear
following inhalation of a dose of 81 mg/kg, which is well below the
level detectable by odour (243 mg/kg) and far below the probably fatal
dose. Based on these results, the LC0 was established to be equal
or greater than 243 mg/kg.
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