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CAS number: -
Table 1:Individual animal clinical signs of toxicity and
Phase of the Experiment
Dose (mg/kg body weight)
Time of Dosing
Clinical Signs of Toxicity and Mortality on Day 1
Clinical Signs of Toxicity and Mortality on days
Range Finding Study
N: Normal; F: Female; min: minutes; hr/hrs: hour/hours
Table 2: Individual animal body weight (g) and percent change in
body weight with respect to day 1
Body Weight (g) on Days
Percent Change in Body Weight with Respect to Day
1 to 8
1 to 15
The acute dermal toxicity of the test item was studied according to OECD
Guideline 402 (GLP study). 5 female Sprague-Dawley rats were tested for
a exposure period of 24 h. Initially, a range finding study was
conducted at doses of 200, 1000 and 2000 mg/kg bw in one animal per
dose. Based on the results of this preliminary study two additional rats
were tested at a dose of 2000 mg/kg bw. No treatment related clinical
signs of toxicity and mortality were observed. The body weight
evolution of the animals remained normal during the study. The
macroscopic examination of the animals at the end of the study did not
reveal treatment related effects. Based on these results, the
test item was found to be non toxic, with an LD50 > 2000 mg/kg bw.
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