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EC number: 949-219-1
CAS number: -
endpoint values to Daphnia magna(48h-EC50) used within the
calculation method to determine WAF aquatic toxicity to Daphnia magna.
48h-EC50 (mg.L-1) used
Concentration of each constituent
in the WAF of the test substance at 30 mg/L (i.e. the EL50)
concentration in the WAF (mg.L-1)
This approach uses a
thermodynamically based module to calculate the water concentrations and
the individual toxicity of each of the constituent is first derived from
a QSAR model validated to be compliant with the OECD recommandations for
QSAR modeling (OECD, 2004). Then the effective loading rate of the
mixture to the test organisms (i.e. Daphnia magna) is determined as a
Water Accommodated Fraction (WAF) test (OECD, 2000).
The inputs into the model all came
from reliable QSAR estimations. The endpoint value is considered valid
for use in risk assessment (including PBT assessment) and classification
and labelling. The prediction is adequate as contributing data for the
Classification and Labelling or risk assessment of the substance as
indicated in REACH Regulation (EC) 1907/2006: Annex XI Section 1.3.
The 48 hour EL50 for the test
substance was estimated to be 30 mg/L.
48 h EL50 30 mg/L, REACH guidance
on QSARs R.6, OECD Guideline 202 (Acute Daphnia sp. Immobilisation
Test), with modifications from OECD Series on Testing and Assessment no.
23 on ecotoxicity testing of difficult substances, Thomas 2016.
A supporting study on the acute toxicity
of the substance to Daphnia magna was also conducted in accordance with OECD
202 (Anon. 2017). The EL50 was determined following 48h exposure of daphnids
to water accommodated fractions of the test item, thus creating the conditions
under which the key (Q)SAR predictions were made. The resulting 48h EL50
was estimated as 9.84 mg/L (95 % CI: 9.16 -10.7). The results of this study
support the magnitude of the key effect levels generated by each (Q)SAR study
for Daphnia and alge, providing further evidence of their relevance and reliability
for these endpoints.
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