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EC number: 949-219-1
CAS number: -
endpoint values to algae (72h-ErC50) used within the calculation method
to determine WAF aquatic toxicity to algae.
72h-ErC50 (mg.L-1) used
Concentration of each constituent
in the WAF of the test substance at 44 mg/L (i.e. the ErL50)
concentration in the WAF (mg.L-1)
The approach uses a
thermodynamically based module to calculate the water concentrations and
the individual toxicity of each of the constituent is first derived from
a QSAR model validated to be compliant with the OECD recommandations for
QSAR modeling (OECD, 2004). Then the effective loading rate of the
mixture to the test organisms (i.e. algae) is determined as a Water
Accommodated Fraction (WAF) test (OECD, 2000).
The inputs into the model all came
from reliable QSAR estimations. The endpoint value is considered valid
for use in risk assessment (including PBT assessment) and classification
and labelling. The prediction is adequate as contributing data for the
Classification and Labelling or risk assessment of the substance as
indicated in REACH Regulation (EC) 1907/2006: Annex XI Section 1.3.
The 72 hour ErL50 for the test
substance was estimated to be 44 mg/L.
72 h ErL50 44 mg/L, REACH guidance
on QSARs R.6, OECD Guideline 201 (Freshwater Alga and Cyanobacteria
Growth Inhibition Test), with modifications from OECD Series on Testing
and Assessment no. 23 on ecotoxicity testing of difficult substances,
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