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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Study starting date: 2017-09-25; Experimental starting date: 2017-11-01; Experimental completion date: 2017-11-01
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
Qualifier:
according to guideline
Guideline:
ISO 13320 (Particle size analysis - Laser diffraction methods)
GLP compliance:
yes (incl. QA statement)
Type of method:
Laser scattering/diffraction
Type of particle tested:
agglomerate
Key result
Percentile:
D10
Mean:
7.3 µm
St. dev.:
0.3
Key result
Percentile:
D50
Mean:
193.6 µm
St. dev.:
7.4
Key result
Percentile:
D90
Mean:
890.1 µm
St. dev.:
50.7

Two test series of 3 measurements each were performed with the test item.

 

Test series 1:

D10:       7.1 µm

D50:       188.3 µm        (Median diameter)

D90:       854.2 µm

 

Test series 2:

D10:       7.5 µm

D50:       198.8 µm        (Median diameter)

D90:       926.0 µm

 

Average:

D10:       7.3 µm

D50:       193.6 µm        (Median diameter)

D90:       890.1 µm

Conclusions:
Dilithium salicylate has a median particle size D50 = 194 µm, which was determined by laser diffraction measurement.
Executive summary:

The test item, Dilithium salicylate, has a median particle size D50 = 194 µm, which was determined by laser diffraction measurement.

This study is GLP compliant and follows OECD guideline 110 (1981) and ISO 13320 (2009). Therefore, it is given a reliability rating of 1 (reliable without restrictions).

Description of key information

The test item, Dilithium salicylate, has a median particle size D50 = 194 µm, which was determined by laser diffraction measurement.

Additional information

This study is GLP compliant and follows OECD guideline 110 (1981) and ISO 13320 (2009). Therefore, it is given a reliability rating of 1 (reliable without restrictions).