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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Secondary source.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1978

Materials and methods

Test guideline
Qualifier:
no guideline available
Deviations:
not specified
Principles of method if other than guideline:
A single application of 0.1 ml of 2,4-dichlorophenol was applied to the eyes. After 30 seconds the eyes were washed/rinsed. 2,4-Dichlorophenol is a solid at room temperature. This reference states that 0.1 ml of the test substance was administered. It is therefore assumed that it was melted prior to administration.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dichlorophenol
EC Number:
204-429-6
EC Name:
2,4-dichlorophenol
Cas Number:
120-83-2
Molecular formula:
C6H4Cl2O
IUPAC Name:
2,4-dichlorophenol
Details on test material:
No additional details presented

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No additional data presented

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
0.1 ml of neat substance applied. Since 2,4-Dichlorophenol is a solid at room temperature it is assumed that it was melted prior to administration.
Duration of treatment / exposure:
30 seconds
Observation period (in vivo):
Immediate
Number of animals or in vitro replicates:
Not stated
Details on study design:
No additional data presented

Results and discussion

In vivo

Results
Irritation parameter:
other: No scores given but severe corneal damage observed afer a single application following which the eyes were rinsed after 30 seconds
Reversibility:
not reversible
Irritant / corrosive response data:
Severe corneal damage was observed after a single application of 0.1 ml of the test substance. Washing/rinsing of the eyes after 30 seconds did not prevent the observed corneal damage.
Other effects:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance is regarded as corrosive
Executive summary:

0.1 ml of the test substance (presumably at > 45°C, the melting point of 2,4 -dichlorophenol) was applied to the eyes of rabbits (number of animals is not known). No information on the guideline followed or the method employed is given. No information is given regarding GLP. After 30 seconds the eyes were washed/rinsed. Severe corneal damage was observed and the washing /rinsing of the eyes did not prevent the corneal damage.