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EC number: 220-011-6 | CAS number: 2602-34-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01.12.1981 to 17.12.1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an appropriate OECD/EU test guideline, and in compliance with GLP, and was considered to be reliability 1 (reliable without restrictions). Read across to the registered substance is considered scientifically justified
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- [3-(2,3-epoxypropoxy)propyl]trimethoxysilane
- EC Number:
- 219-784-2
- EC Name:
- [3-(2,3-epoxypropoxy)propyl]trimethoxysilane
- Cas Number:
- 2530-83-8
- Molecular formula:
- C9H20O5Si
- IUPAC Name:
- Trimethoxy-[3-(oxiran-2-ylmethoxy)propyl]silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, New York.
- Age at study initiation: 9-11 weeks
- Weight at study initiation: Not defined
- Fasting period before study: No data
- Housing: Individually in suspended wire mesh-bottom exposure cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Four weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 71-73 (22-23 °C)
- Humidity (%): 69-78
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 01.12.1981 To: 17.12.1981
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel and glass exposure chamber.
- Exposure chamber volume: 225 litre.
- Method of holding animals in test chamber: none
- Source and rate of air: Room air. Flow rate of 50 l/minute.
- Method of conditioning air: No data.
- System of generating particulates/aerosols: Spraying Systems 1/4 (?) J Nebulizer.
- Method of particle size determination: cascade impaction.
- Treatment of exhaust air: No data
- Temperature, humidity, pressure in air chamber: Temperature (°F): 71-73 (22-23 °C); Humidity (%): 69-78.
TEST ATMOSPHERE
Mass median aerodynamic diameter was determined hourly by cascade impaction for each exposure level and ranged from 1.4 to 2.0 microns. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric methods and gas chromatography (considered secondary due to recovery inefficiencies, however, gas chromatographic values averaged 85% of the gravimetrically determined concentrations).
- Duration of exposure:
- 4 h
- Concentrations:
- 0.8, 1.9, and 5.3 mg/L
- No. of animals per sex per dose:
- 30
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily observations. Weighing on 1, 2, 4 or 5, 7 and 14 days after exposure.
- Necropsy of survivors performed: yes
- Other examinations performed: gross necropsy. - Statistics:
- No details.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.3 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- No deaths occurred at the two lower concentrations (1.9 and 0.8 mg/L). At the highest concentration (5.3 mg/L), three rats died, one male on day 1, one female on day 1 and one female on day 2.
- Clinical signs:
- other: Following exposures, all rats exhibited varying amounts of test substance contamination on the fur. Clinical signs included excessive lacrimation, dry and moist rales, nasal discharge, and yellow staining in the anal-genital area. These signs were consi
- Body weight:
- There was also a transient dose-related body weight depression seen in all groups (including the control) during the first week, however, mean body weights exceeded pre-exposure values by day 14 in all groups.
- Gross pathology:
- Discolored lungs and autolytic changes were seen in the three rats that died. There were no gross abnormalities noted at the necropsy of survivors.
Any other information on results incl. tables
Table of concentrations and particle sizing data of Prylog (mg/l and µm)
Group | Method | Mean conc./mean MMD | Hourly air samples mg/l/MMD | Nominal conc. | |||
1 | 2 | 3 | 4 | ||||
1 | Analytical | 4.8 | 4.0 | 4.9 | 5.2 | 4.9 | 25.3 |
Gravimetric | 5.3/1.9 | 5.7/2.0 | 5.4/1.8 | 5.4/1.8 | 4.7/1.8 | ||
2 | Analytical | 1.7 | 1.7 | 1.8 | 1.8 | 1.4 | 7.1 |
Gravimetric | 1.9/1.7 | 0.9/1.7 | 2.5/1.6 | 2.1/1.6 | 2.0/1.7 | ||
3 | Analytical | 0.6 | 0.7 | 0.6 | 0.6 | 0.6 | 2.3 |
Gravimetric | 0.8/2.0 | 1.1/1.6 | 0.7/1.5 | 0.7/1.4 | 0.6/1.5 | ||
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- In a good quality acute inhalation study (reliability score 1) conducted to OECD 403, and in compliance with GLP, an aerosol of unchanged [3-(2,3-epoxypropoxy)propyl]trimethoxysilane gave an LC50 greater than 5.3 mg/l in rats.
- Executive summary:
In a good quality acute inhalation study (reliability score 1) conducted according to OECD 403, and in compliance with GLP, an aerosol of unchanged [3-(2,3-epoxypropoxy)propyl]trimethoxysilane gave an LC50 greater than 5.3 mg/l in rats.
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