[3-(2,3-epoxypropoxy)propyl]triethoxysilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18.08.1994 to 08.09.1994

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1994

Report date:

1994

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 (Acute Toxicity (Oral))

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OTS 798.1175 (Acute Oral Toxicity)

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

[3-(2,3-epoxypropoxy)propyl]triethoxysilane

EC Number:

220-011-6

EC Name:

[3-(2,3-epoxypropoxy)propyl]triethoxysilane

Cas Number:

2602-34-8

Molecular formula:

C12-H26-O5-Si

IUPAC Name:

triethoxy[3-(oxiran-2-ylmethoxy)propyl]silane

Details on test material:

- Name of test material (as cited in study report): Wacker Silane GF 82
- Substance type: Alkoxysilane
- Physical state: Colourless liquid
- Stability under test conditions: Stable
- Storage condition of test material: In original container, kept closed, at room temperature away from direct sunlight, acids, bases and oxidising agents.

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: BRL, Biological Research Laboratories Ltd., Switzerland
- Age at study initiation: Males: 8 weeks; Females: 10 weeks
- Weight at study initiation: Males: 198.4 - 210.4 g; Females: 176.8-181.4 g
- Fasting period before study: yes
- Housing: Groups of five in Makrolon type IV cages
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: One week

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 ±2
- Humidity (%): 49-72
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12

IN-LIFE DATES: From: 25.08.1994 To: 08.09.1994

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

Five

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Each animal was examined for changes in appearance and behaviour four times during day 1, and once daily during days 2-15. Body weights were recorded on test day 1 (pre-administration), 8 and 15.
- Necropsy of survivors performed: yes
- Other examinations performed: Macroscopic examination only

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No deaths

Mortality:

No deaths occurred.

Clinical signs:

other: There were no clinical signs of toxicity.

Gross pathology:

No abnormal findings .

Other findings:

None

Applicant's summary and conclusion

Interpretation of results:

not classified

Conclusions:

In an acute oral toxicity study conducted to OECD Test Guideline 401 and in compliance with GLP (reliability score 1) the LD50 for [3-(2,3-epoxypropoxy)propyl]triethoxysilane was >2000 mg/kg bw in rats.