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EC number: 220-011-6
CAS number: 2602-34-8
(48-h) EC50: >100 mg/l, nominal, Daphnia magna, reliability 1.
A 48-hour EC50 value of >59 mg/l and a NOEC of ≥59 mg/l
have been determined for the effects of the registered substance on
mobility of Daphnia magna based on geometric mean measured
exposure concentrations. The corresponding nominal exposure
concentration was 100 mg/l. It is likely that the test organisms were
exposed to a mixture of parent substance and hydrolysis products. The
results are assessed on the basis of nominal concentrations because it
is not possible to establish the identity of the substance(s) that the
analysis relates to (see section 7.1.1).
The results of a supporting study with the registered substance
are also available. A 48-h EL50 value of ≥100 mg/l has been
determined for the effects of the substance on mobility of Daphnia
magna based on nominal test substance loading rate. A corresponding
48-h EC50 of ≥40 mg/l has been determined by the reviewer
based on measured DOC concentration. A reliable NOELR/NOEC cannot be
determined from the test results because corresponding test media were
prepared by dilution of a filtered stock dispersion. The results of a
second test conducted as part of this study have been discounted because
the test media preparation regime included a stirring period of 48 hours
and the pH of the test medium was relatively high (7.7. to 8.4). At this
pH it is estimated that the substance will hydrolyse 5 to 10 times
faster than the measured hydrolysis half-life: 12 – 36 h at pH 7 and
25°C (OECD 111). Therefore the test organisms were predominantly exposed
to the hydrolysis product of the substance.
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