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EC number: 219-755-4
CAS number: 2524-04-1
Mortality ratio and group mean bodyweight
of mice dosed orally at EP2 - Results of the full scale test:
Dosage [mL/kg bw]
Bodyweight [g] at
(No. dead / No. dosed)
Time of death after dosing [h]
0 / 5
2 / 5
4 / 5
5 / 5
1 / 5
The study was conducted in order to assess
the acute oral toxicity of EP2 (O,O-diethyl chlorothiophosphate).
Therefore, mice were treated at a single
dose of 0 - 2.5 mL of a 5% solution of the test substance in an aqueous
solution containing 5% Tween 80 (dosage sorresponds to 0 - 2975 mg/kg
During a 14 day post-exposure period,
mortalities and signs of toxicity were recorded. All mice that died and
those that survived the observation period were subjected to autopsy, in
an attempt to identify the target organs.
Signs of reaction to treatment included
piloerection and lethargy (all animals), body tremors (>0.4 mL/kg bw)
and excess salivation (0.64 and 1 mL/kg bw). Death occured between one
and 24 hours after test substance administration. Autopsy revealed
darkening of liver and kidneys and injection of the intestinal blood
vessels. Recovery of survivors was complete within one day of treatment
and no adverse findings were made during autopsy. Bodyweights were not
affected by treatment, except in one female which survived treatment at
1 mL/kg bw, where reduced bodyweight gain was noted during the first
week after exposure, but not during week 2 after dosage.
Based on the results, the LD50 was
calculated to be 0.6 mL/kg bw (corresponding to 714 mg/kg bw).
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