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EC number: 219-755-4
CAS number: 2524-04-1
Results of skin irritation/corrosion
assay of EP2 in rabbits:
Exposure time: 3 minutes
Erythema – Eschar observed at hours
Oedema observed at hours
Mean of all rabbits: 3.3
Mean of all rabbits: 3.9
Exposure time: 1 hour
Mean of all rabbits: 4.0
Mean scores for the individual animal were calculated by adding
the scores obtained at 24, 48 and 72 hours and dividing by 6.
The primary skin irritant effect of EP-2 was
investigated according to OECD guideline 404. Possible skin irritating /
corrosive effects were studied after 3 minutes and 1 hour exposure in 4
The mean scores (24, 48 and 72 hours after
application) after 3 minutes of exposure were 3.3 for erythema and 3.9
for oedema in all animals combined. After one hour of exposure, the mean
scores (24, 48 and 72 hours) were3.3 for erythema and 4.0 for oedema for
all animals combined. Furthermore, scar formation was observed in three
of the rabbits exposed for one hour.
According to the Official Journal of the
European Commumities, L 257, 1983, EP-2 shall be classified as skin
irritating after 3 minutes of exposure and as corrosive after one hour
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