Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-755-4
CAS number: 2524-04-1
No other information.
A subacute inhalation toxicity study was
performed for 109 industrial chemicals, including O,O-diethyl
Rats were exposed for 4 -5 hours per day for
2 (high dose) or 14 days (medium and low dose) towards 104, 20 or 5 ppm
of O,O-diethyl phosphorochloridothionate. The test atmosphere was
generated by injecting the liquid at a known rate into a metered stream
of air. Rats were weighed and observed for condition and behaviour each
day and urine was collected overnight for biochemical analysis. At the
end of the study, blood was taken for haematological tests and gross
examination of organs and histopathology were performed.
Results revealed that even at the lowest
concentration, O,O-diethyl phosphorochloridothionate resulted in
irritation of the nose and thickening of alveolar walls in the lungs.
With rising concentration of the test substance, more signs of
irritation and breathing difficulties were observed.
It is concluded that O,O-diethyl
phosphorochloridothionate is an irritant at concentrations of 5 - 104 ppm
(corresponding to 0.5 - 10.4 mg/mL) in air.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again