Registration Dossier
Registration Dossier
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EC number: 285-206-0 | CAS number: 85049-36-1
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of Fatty acids, C16-18 and C18-unsatd., ethyl esters (CAS 85049-36-1) to aquatic invertebrates is not available. The assessment was therefore based on a study conducted with the structurally similar substance Fatty acids, C16-18 and C18-unsaturated isobutyl esters (CAS 84988-79-4) and Isopropyl oleate (CAS 112-11-8) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The study conducted with Fatty acids, C16-18 and C18-unsaturated isobutyl esters (CAS 84988-79-4) was performed as a limit test according to EU guideline 92/69/EWG and GLP (Wierich, 1995). The test organism Daphnia magna was exposed to the test substance in a static system for 48 hours. Three different methods were applied for the preparation of test solutions: 1) direct addition to nominal 100 mg/L without separation of undissolved test material, 2) direct addition to nominal 100 mg/L followed by a separation of undissolved test material and 3) 3 to 5 fold saturation concentration without separation of undissolved material. Immobilisation was observed only in the test solutions prepared using the first method, and was therefore probably due to physical effects caused by the large amount of undissolved test material present in the test solution. With separation of undissolved test material and with 3 to 5 fold saturation no negative effects were observed. It can be concluded that the test substance had no toxic effects on Daphnia magna up to the limit of water solubility. An EL50 of > 100 mg/L was reported.
The supporting study conducted with Isopropyl oleate (CAS
112-11-8) was performed according to the guideline AEP2 issued by the
Ministry of Agriculture, Fisheries and Food of the United Kingdom (1984)
(Clitherow, 1991). The marine test organism Crangon crangon was exposed
to the test substance in a static system for 48 hours, at nominal test
concentrations of 850, 1530, 2640, 4760 and 8500 mg/L. No mortality was
observed at any of the test concentrations.
Based on the results of the read across substance toxic effects of Fatty
acids, C16-18 and C18-unsatd., ethyl esters (CAS 85049-36-1) to aquatic
invertebrates are not expected.
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