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EC number: 931-607-7
CAS number: -
No information on animal testing of "Lead bullion, Platinum Group metals rich" is available. However, "Lead bullion, Platinum Group metals rich" does not contain any constituent ≥ 0.1 % which is classified as a Carc. 1A or Carc. 1B carcinogen but contains ≥ 1 % nickel powder, respectively, that is classified as a Carc. 2 carcinogen. Hence, "Lead bullion, Platinum Group metals rich" must be classified to induce cancer (Carc. 2).
bullion, Platinum Group metals rich refining is a complex metal
containing UVCB substance with wide concentration ranges for each
constituent. Each individual constituent of Lead bullion, Platinum Group
metals rich refining may contribute (as 'relevant' component) to the
UVCB toxicity. With knowledge of the composition, mineralogical
information and knowledge of corresponding toxicity of the various
chemical species, the respective mixture rules in accordance with
Regulation (EC) 1272/2008 are used to calculate the C&L of Lead bullion,
Platinum Group metals rich refining.
used to automatically calculate the classification of the UVCB
substance. The calculation tool is based on a database containing the
human and environmental hazard information for each component relevant
for classification. The information on the representative mineralogical
composition (distribution pattern for each constituent of the UVCB
substance) is incorporated into MeClas as well.
derived hazard category (output of MeClas) the corresponding human
health (HH) toxicity value was deduced.
following data were used as input of MeClas:
Classification from individual components according to Annex VI of the
CLP regulation (Regulation (EC) 1272/2008) and the 2nd ATP to this
regulation, unless additional information on self-classification was
Percentage of the components in the UVCB: individual total element
concentrations (percentages based on total substance amount) were
recalculated into percentage of the classified chemical species (i.e.
substance), taking into account the distribution pattern of the
respective element in its present various mineral forms if such
information was available.
described MeClas-based-calculation provides a conservative estimate of
toxicological effects of "Lead bullion, Platinum Group metals rich",
derived on basis of the mixture C&L rules set forth in Regulation (EC)
1272/2008 using mineralogical information from a representative/worst
classification of UVCB substances is based on the presence of a
constituent ≥ 0.1 % classified for carcinogenicity Carc. 1A or Carc. 1B
and on the presence of a constituent ≥ 1 % classified for
carcinogenicity Carc. 2, respectively. "Lead bullion, Platinum Group
metals rich" does not contain any constituents ≥ 0.1 % classified for
carcinogenicity Carc. 1A or Carc. 1B but constituents ≥ 1 % classified
for carcinogenicity Carc. 2 (i.e., nickel powder). Hence, "Lead bullion,
Platinum Group metals rich" is considered to induce cancer and does
require classification as carcinogenic Carc. 2 (H351), in accordance
with Regulation (EC) 1272/2008.
specific information for the UVCB substance "Lead bullion, Platinum
Group metals rich" is not available for the endpoint
"Carcinogenicity". In order to meet the requirements for Annex VII till
Annex X of Regulation (EC) 1907/2006, read across information from any
constituents being relevant needs to be included. Due to the high number
of constituents and variability in C&L of
these constituents it was decided to use the classification information
from the individual constituents and to calculate the resulting
classification by using the“generic
concentration limits of ingredients of the mixture classified as
carcinogen that trigger classification of the mixture” and
respective rules of Regulation (EC) 1272/2006 section 220.127.116.11 “Classification
of mixtures when data are available for all ingredients or only for some
ingredients of the mixture” with the MeClas tool. This
approach has been presented and discussed with ECHA in several meetings.
"Lead bullion, Platinum Group metals rich" one C&L entry
(i.e., carcinogenic Carc. 2) for carcinogenicity were calculated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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