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EC number: 931-607-7
CAS number: -
No information on animal testing of “Lead bullion, Platinum Group metals rich” is available. However, “Lead bullion, Platinum Group metals rich” with a lead powder and nickel powder content of ≥ 1 % is considered to be toxic to specific target organs following repeated dosing via the oral route and meets classification criteria for STOT-RE 1; H372.
bullion, Platinum Group metals rich refining is a complex metal
containing UVCB substance with wide concentration ranges for each
constituent. Each individual constituent of Lead bullion, Platinum Group
metals rich refining may contribute (as 'relevant' component) to the
UVCB toxicity. With knowledge of the composition, mineralogical
information and knowledge of corresponding toxicity of the various
chemical species, the respective mixture rules in accordance with
Regulation (EC) 1272/2008 are used to calculate the C&L of Lead bullion,
Platinum Group metals rich refining.
used to automatically calculate the classification of the UVCB
substance. The calculation tool is based on a database containing the
human and environmental hazard information for each component relevant
for classification. The information on the representative mineralogical
composition (distribution pattern for each constituent of the UVCB
substance) is incorporated into MeClas as well.
derived hazard category (output of MeClas) the corresponding human
health (HH) toxicity value was deduced.
following data were used as input of MeClas:
Classification from individual components according to Annex VI of the
CLP regulation (Regulation (EC) 1272/2008) and the 2nd ATP to this
regulation, unless additional information on self-classification was
Percentage of the components in the UVCB: individual total element
concentrations (percentages based on total substance amount) were
recalculated into percentage of the classified chemical species (i.e.
substance), taking into account the distribution pattern of the
respective element in its present various mineral forms if such
information was available.
described MeClas-based-calculation provides a conservative estimate of
toxicological effects of "Lead bullion, Platinum Group metals rich",
derived on basis of the mixture C&L rules set forth in Regulation (EC)
1272/2008 using mineralogical information from a representative/worst
specific information for the UVCB substance "Lead bullion, Platinum
Group metals rich" is not available for the endpoint "Repeated Dose
Toxicity". In order to meet the requirements for Annex VII till Annex X
of Regulation (EC) 1907/2006, read across information from any
constituents being relevant needs to be included. Due to the high number
of constituents and variability in C&L of these constituents it was
decided to use the classification information from the individual
constituents and to calculate the resulting classification by using the generic
concentration limits of ingredients of the mixture classified as a
specific target organ toxicant that trigger classification of the mixture
and respective rules of Regulation
(EC) 1272/2006 section 188.8.131.52 “Classification of mixtures when
data are available for all components or only for some components of the
mixture” with the MeClas tool. This approach has been presented and
discussed with ECHA in several meetings.
For "Lead bullion, Platinum Group
metals rich" one C&L entry (i.e., STOT RE 1) for repeated dose toxicity
of UVCB substances as being toxic to specific target organs is based on
the presence of one or more constituents ≥ 1 % classified for STOT RE 1
and the presence of one or more constituents ≥ 10 % classified for STOT
RE 2. Since, “Lead bullion, Platinum Group metals rich” contains ≥ 1%
lead powder and nickel powder classified as STOT RE 1
(self-classification), “Lead bullion, Platinum Group metals rich” meets
classification criteria for STOT RE 1 and requires labelling with H372
(causes damage to organs) as required in accordance with Regulation (EC)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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