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EC number: 931-607-7
CAS number: -
No information on animal testing of "Lead bullion, Platinum Group metals rich" on acute toxicity is available. The C&L was determined by using the “acute toxicity range estimate (ATE)” and respective rules of Regulation (EC) 1272/2006 section 220.127.116.11 “Classification of mixtures based on ingredients of the mixture”. Applying these rules the converted acute toxicity point estimate value for acute toxicity, oral route is 500 mg/kg bw in accordance with EU CLP Guidance Annex I Table 3.1.2. No C&L for acute inhalation toxicity and toxicity via skin is required.
bullion, Platinum Group metals rich refining is a complex metal
containing UVCB substance with wide concentration ranges for each
constituent. Each individual constituent of Lead bullion, Platinum Group
metals rich refining may contribute (as 'relevant' component) to the
UVCB toxicity. With knowledge of the composition, mineralogical
information and knowledge of corresponding toxicity of the various
chemical species, the respective mixture rules in accordance with
Regulation (EC) 1272/2008 are used to calculate the C&L of Lead bullion,
Platinum Group metals rich refining.
used to automatically calculate the classification of the UVCB
substance. The calculation tool is based on a database containing the
human and environmental hazard information for each component relevant
for classification. The information on the representative mineralogical
composition (distribution pattern for each constituent of the UVCB
substance) is incorporated into MeClas as well.
derived hazard category (output of MeClas) the corresponding human
health (HH) toxicity value was deduced.
following data were used as input of MeClas:
Classification from individual components according to Annex VI of the
CLP regulation (Regulation (EC) 1272/2008) and the 2nd ATP to this
regulation, unless additional information on self-classification was
Percentage of the components in the UVCB: individual total element
concentrations (percentages based on total substance amount) were
recalculated into percentage of the classified chemical species (i.e.
substance), taking into account the distribution pattern of the
respective element in its present various mineral forms if such
information was available.
described MeClas-based-calculation provides a conservative estimate of
toxicological effects of "Lead bullion, Platinum Group metals rich",
derived on basis of the mixture C&L rules set forth in Regulation (EC)
1272/2008 using mineralogical information from a representative/worst
specific information for the UVCB substance "Lead
bullion, Platinum Group metals rich" as
such is not available for the endpoint "Acute Toxicity". In order to
meet the requirements for Annex VII - Annex X of Regulation (EC)
1907/2006, read across information from any constituent being relevant
needs to be included. Due to the high number of constituents and
variability in C&L of these constituents it was decided to use the
classification information from the individual constituents and to
calculate the resulting classification by using the “acute toxicity
range estimate (ATE)” and respective rules of Regulation (EC) 1272/2006
section 18.104.22.168 “Classification of mixtures based on ingredients of the
mixture” with the aid of the MeClas tool. This approach has been
presented and discussed with ECHA in several meetings.
For "Lead bullion, Platinum Group
metals rich" one C&L entry (i.e., harmful if swallowed) for acute
toxicity were calculated.
available information indicates that "Lead bullion, Platinum Group
metals rich" is harmful via ingestion, but not acutely toxic or harmful
via the dermal and inhalation route. Lead bullion, Platinum Group metals
rich requires classification as harmful if swallowed (Acute Tox. 4)
according to Regulation (EC) 1272/2008. Classification of "Lead bullion,
Platinum Group metals rich" for acute toxicity via the dermal and
inhalation route is not required according to Regulation (EC) 1272/2008.
target organ toxicant (STOT) - single exposure: oral, inhalation and
classification criteria according to Regulation (EC) 1272/2008 as
specific target organ toxicant (STOT) – single exposure are not met
since no adverse health effects, including reversible and irreversible,
were observed immediately or delayed after exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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